Description : Essential Formulas . Professional Formula . Dietary Supplement . Unique 5-year Fermentation Process. Developed by award-winning microbiologist lichiroh Ohhira, Ph.D., and research scientists from Okayama University, this formula combines ancient Japanese fermentation techniques with modern technology. Twelve strains of lactic acid bacteria, including super potent TH10, are used in the fermentation of vegetables, fruits, seaweeds and mushrooms. Our biogenic matrix (the rich culture medium pre-biotic and natural organic acids) improves the gut environment and is what distinguishes this product from mere probiotics. Dr. Ohhira's Probiotics 12 Plus Professional Formula differs from the Original Formula in that after 3 years of fermentation, it receives two additional years of maturing. Dr. Ohhira's Probiotics is a registered trademark of Essential Formulas. 100% vegan . No dairy, soy or gluten . Non-GMO, chemical-free . Blister-packed to ensure product integrity . Refrigeration not required . Product of Japan . Suggested Use . 2 capsules daily or as directed by your health professional. (Children under age 6: 1 capsule daily.) For best results, take 1 capsule with water twice a day on an empty stomach. If benefits are desired in the stomach (e.g. heartburn or an unsettling meal) the capsules may be chewed. Temporary reactions such as minor bloating or a mild laxative or constipating effect are signs that the beneficial bacteria are remodeling, detoxifying and improving the gut environment. (If such transition effects last more than 14 days, consult your health professional). Other Ingredients : Mountain spring water, safflower oil, beeswax, lecithin, capsule (tapioca processed from Manihot utilissima root, glycerin, carrageenan and carmel color.) Lactic acid bacteria used in fermentation: Bifidobacterium breve ssp. breve, Bifidobacterium infantis ssp. infantis, Bifidobacterium longum, enterococcus faecalis TH10, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus bulgaricus, Lactobacillus casei ssp. casei, Lactobacillus fermentum, Lactobacillus helveticus ssp. jugurti, Lactobacillus plantarum, Streptococcus thermophilus. Warnings : Keep out of reach of children. If pregnant or nursing, ask a health professional before use. Tamper evident: Do not use if foil blister pack is broken. .